Four makeshift hospitals and a local blood bank in Syria's battered Aleppo city have been hit by air raids in the past 24 hours, a group of doctors said Sunday.
Islamic State group militants clashed on Saturday with US-backed fighters in the Syrian town of Manbij, pursuing their fierce defence of the jihadist stronghold and ignoring a deadline to leave.
Russian warplanes bombed a remote outpost in Syria used by elite US and British forces last month as well as another site linked to the CIA, the Wall Street Journal reported Friday.
Top diplomatic and military officials from the US-led coalition fighting the Islamic State group met on Thursday to prepare the assault on its Iraqi bastion Mosul.
A US-backed force fighting to drive Islamic State out of Manbij said on Thursday it was giving the jihadist group 48 hours to pull out of the surrounded northern Syrian city.
The head of the opposition Syrian National Coalition called for a suspension of the US-led air campaign against Islamic State in Syria while reports of dozens of civilian deaths from air strikes around the northern city of Manbij are investigated.
Syrian residents and the opposition expressed outrage on Wednesday at the brutal beheading of a child by a rebel group in Aleppo city, branding it a "heinous act".
Syrian rebels and a monitoring group said two explosions that struck a Syrian town near the Israeli-occupied Golan Heights were caused by an Israeli air strike but Lebanon's Hezbollah blamed rocket fire by al Qaeda-linked militants.
Air strikes by the US-led coalition killed at least 21 civilians in and around a stronghold of the Islamic State group in northern Syria on Monday, a monitor said.
Opposition-controlled parts of Syria's battered northern city Aleppo came under total siege on Sunday, after government forces severed the last route out of the east.
Air raids on rebel-held districts of Syria's battleground second city of Aleppo killed at least 25 civilians including children on Saturday, a monitor said.
US investigations have exposed bribery and fraud in Syrian aid programmes, the United States Agency for International Development (USAID) said, raising concern about profiteering in the humanitarian sector.