Dr. Deborah Persaud of Johns Hopkins’ Children’s Centre in Baltimore. A team of medical researchers announced on Sunday what they said was the first case of a “functional cure” in an infant infected with HIV, the virus that causes Aids.

AFP/Washington

Researchers said on Sunday they had, for the first time, cured a baby born with HIV - a development that could help improve treatment of babies infected at birth.

There is an important technical nuance: researchers insist on calling it a “functional cure” rather than a complete cure.

That is because the virus is not totally eradicated. Still, its presence is reduced to such a low level that a body can control it without the need for standard drug treatment.

The only fully cured Aids patient recognised worldwide is the so-called “Berlin patient,” American Timothy Brown. He is considered cured of HIV and leukemia five years after receiving bone marrow transplants from a rare donor naturally resistant to HIV. The marrow transplant was aimed at treating his leukemia.

But in this new case, the baby girl received nothing more invasive or complex than commonly available antiretroviral drugs. The difference, however, was the dosage and the timing: starting less than 30 hours after her birth.

It is that kind of aggressive treatment that likely yielded the “functional cure,” researchers reported at the 20th annual Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta, Georgia.

What researchers call dormant HIV-infected cells often re-start infections in HIV-infected patients within a few weeks after antiretroviral treatment stops, forcing most people who have tested HIV-positive to stay on the drugs for life or risk the illness progressing.

“Prompt antiviral therapy in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place,” said lead researcher Deborah Persaud, of Johns Hopkins Children’s Center in Baltimore, Maryland.

It appears to be the first time this was achieved in a baby, she said.

The baby was infected by her HIV-positive mother, and her treatment with therapeutic doses of antiretroviral drugs began even before her own positive blood test came back.

The typical protocol for high-risk newborns is to give them smaller doses of the drugs until results from an HIV blood test is available at six weeks old.

Tests showed the baby’s viral count steadily declined until it could not longer be detected 29 days after her birth.

The child was given follow-up treatment with antiretrovirals until 18 months, at which point doctors lost contact with her for 10 months. During that period she was not taking antiretrovirals.

Researchers then were able to do a series of blood tests - and none gave an HIV-positive result.

Natural viral suppression without treatment is an exceedingly rare occurrence, seen in fewer than half a per cent of HIV-infected adults, known as “elite controllers,” whose immune systems are able to rein in viral replication and keep the virus at clinically undetectable levels.

Experts on HIV have long wanted to help all HIV patients achieve elite-controller status. Researchers say this new case offers hope as a game-changer, because it suggests prompt antiretroviral therapy in newborns indeed can do that.

Still, they said, their first priority is learning how to stop transmission of the virus from mother to newborn. ARV treatments of mothers currently stop transmission to newborns in 98% of cases, they say.

The research was funded by the National Institutes of Health and the American Foundation for Aids Research.

HIV infection linked to heart attack risk

Being HIV-positive raises a person’s heart attack risk by about 50%, said a study released yesterday that confirms earlier findings.

The study looked at 82,459 US veterans, the vast majority of them men. It was published in Archives of Internal Medicine, a publication of the Journal of the American Medical Association.

It said that in three age groups, the average incidence of heart attack was consistently and significantly higher for people who are HIV-positive, compared to uninfected veterans.

After adjusting for illness, smoking, alcohol consumption and risk factors such as high blood pressure and cholesterol, the HIV-positive subjects in the study had a 50% higher risk of heart attack than uninfected people.